Microbial sulfation of 8-prenylnaringenin.
نویسندگان
چکیده
Out of 24 fungal strains tested for their ability to transform 8-prenylnaringenin, Syncephalastrum racemosum was found to convert this phytoestrogen to a sulfate derivative. The conjugation with sulfuric acid observed in this study is paralleled in mammals indicating that microbes can be used to mimic mammalian metabolism.
منابع مشابه
Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin.
Hop, an essential ingredient in most beers, contains a number of prenylflavonoids, among which 8-prenylnaringenin (8-PN) would be the most potent phytoestrogen currently known. Although a number of health effects are attributed to these compounds, only a few reports are available about the bioavailability of prenylflavonoids and the transformation potency of the intestinal microbial community. ...
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Hop-derived food supplements and beers contain the prenylflavonoids xanthohumol (X), isoxanthohumol (IX) and the very potent phyto-oestrogen (plant-derived oestrogen mimic) 8-prenylnaringenin (8-PN). The weakly oestrogenic IX can be bioactivated via O-demethylation to 8-PN. Since IX usually predominates over 8-PN, human subjects may be exposed to increased doses of 8-PN. A dietary intervention ...
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ورودعنوان ژورنال:
- Zeitschrift fur Naturforschung. C, Journal of biosciences
دوره 68 5-6 شماره
صفحات -
تاریخ انتشار 2013